Volume 8, Issue 1 (2024)
IQBQ 2024, 8(1): 58-69 |
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Ahmadi H, Bagheri G. Designing a Teriflunomide slow-release system based on a biodegradable composite scaffold poly (glycerin sebacic acid)-co-poly(ε-caprolactone-diol). IQBQ 2024; 8 (1) :58-69
URL: http://arcpe.modares.ac.ir/article-38-78136-en.html
URL: http://arcpe.modares.ac.ir/article-38-78136-en.html
1- Department of Pharmaceutical Chemistry, Shahr.C., Islamic Azad University, Shahriar, Iran.
2- Department of Pharmaceutical Chemistry, Shahr.C., Islamic Azad University, Shahriar, Iran. ,bagheri.gita@yahoo.com
2- Department of Pharmaceutical Chemistry, Shahr.C., Islamic Azad University, Shahriar, Iran. ,
Abstract: (30 Views)
Research subject: The purpose of this research is to prepare three types of biodegradable scaffolds composed of polyglycerin, sebacic acid, and polycaprolactone diol, synthesized with varying molecular weights and polymer concentrations.
Research approach; Polycaprolactone diol (PCL-diol) with different molecular weights was synthesized via ring-opening polymerization. It was then reacted with sebacic acid and glycerol to enhance the hydrophilicity of the resulting polymers. The drug Teriflunomide was loaded into the system, and its release rate was investigated by immersion in a simulated body environment (phosphate buffer, pH = 7.4) using the dialysis bag method.
Main results: FTIR analysis confirmed the presence of ester, ether, and hydroxyl peaks in the structures of all three scaffolds: PGS–PCL-diol 200, PGS–PCL-diol 500, and PGS–PCL-diol 900. The thermal behavior of the scaffolds was characterized using TGA and DSC methods. Results indicated that the PGS–PCL-diol 900 scaffold experienced 15% more weight loss than the other two. The DMTA test showed that the glass transition temperature of PGS–PCL-diol 900 is higher than that of the other scaffolds, and it also demonstrated the highest network density. Degradability analysis revealed that the PGS–PCL-diol 500 scaffold exhibited the highest degradation rate, with 3.9% greater and faster degradation than the other two samples on the second day. SEM images showed that cells effectively penetrated the scaffolds, forming a well-structured three-dimensional network. The MTT test confirmed good cell attachment and scaffold adhesion. In this study, a composite scaffold with a three-dimensional structure was designed and produced in film form. It was cross-linked without any additives, and each analysis was conducted based on variations in polymer chain length and scaffold molecular weight.
Research approach; Polycaprolactone diol (PCL-diol) with different molecular weights was synthesized via ring-opening polymerization. It was then reacted with sebacic acid and glycerol to enhance the hydrophilicity of the resulting polymers. The drug Teriflunomide was loaded into the system, and its release rate was investigated by immersion in a simulated body environment (phosphate buffer, pH = 7.4) using the dialysis bag method.
Main results: FTIR analysis confirmed the presence of ester, ether, and hydroxyl peaks in the structures of all three scaffolds: PGS–PCL-diol 200, PGS–PCL-diol 500, and PGS–PCL-diol 900. The thermal behavior of the scaffolds was characterized using TGA and DSC methods. Results indicated that the PGS–PCL-diol 900 scaffold experienced 15% more weight loss than the other two. The DMTA test showed that the glass transition temperature of PGS–PCL-diol 900 is higher than that of the other scaffolds, and it also demonstrated the highest network density. Degradability analysis revealed that the PGS–PCL-diol 500 scaffold exhibited the highest degradation rate, with 3.9% greater and faster degradation than the other two samples on the second day. SEM images showed that cells effectively penetrated the scaffolds, forming a well-structured three-dimensional network. The MTT test confirmed good cell attachment and scaffold adhesion. In this study, a composite scaffold with a three-dimensional structure was designed and produced in film form. It was cross-linked without any additives, and each analysis was conducted based on variations in polymer chain length and scaffold molecular weight.
Article Type: Original Research |
Subject:
Composite
Received: 2024/11/23 | Accepted: 2024/12/12 | Published: 2024/03/20
Received: 2024/11/23 | Accepted: 2024/12/12 | Published: 2024/03/20
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