Design of Magnetic Chitosan nanoparticles for Targeted Cancer Therapy using 5-Fluorouracil in Glycerol-Moonoleate

Asgarzadeh, Maryam; Shahsavari, Shadab; Vaziri Yazdi, Ali; Moniri, Elham

Design of Magnetic Chitosan nanoparticles for Targeted Cancer Therapy using 5-Fluorouracil in Glycerol-Moonoleate

Authors

M. Asgarzadeh ¹

S. Shahsavari ²

A. Vaziri Yazdi ¹

E. Moniri ³

¹ Department of Chemical engineering, Science and Research branch, Islamic Azad University, Tehran, Iran

² Department of Chemical engineering, Varamin-Pishva branch, Islamic Azad University, Varamin, Iran

³ Department of Chemistry, Varamin-Pishva branch, Islamic Azad University, Varamin, Iran

Abstract

Aim: Most scientists are trying to treat cancer, and in this regard were produced numerous anticancer drugs, that adverse effects on non-target tissue. To overcome this, drugs freight to magnetic nanoparticles Chitosan and its carboxymethyl secondary coumpands are biopolymers that are non-toxic, biodegradable therefore found applications in biomedical field. We explain here that glycerol monooleate covered magnetic nanoparticles (GMO-MNPs) capable of transporting hydrophobic anticancer drugs. Method: In the present study, we have expanded 5-fluorouracil (5-FU) that loaded on chitosan MNPs for targeted cancer therapy. Results: The modified nano-adsorbent was then characterized by Fourier Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), elemental analysis of CHN (9) and thermal weighing analysis (TGA). Lab conditions such as pH, contact time were optimized. To analyze the structure of the sample, X-ray diffraction spectroscopy was used to investigate the magnetic properties of the nanosized particles synthesized by the magnetometer and to detect the phase type formed on the monolayer glycerol matrix network using a polarizing light microscope. Also, the study showed essential oil release in the external environment of 90% for 30 hours. Conclusion: The optimized magnetic nanoparticles according to SEM image, exhibited segregated nanoparticles with sub-spherical smooth morphology and also the high thermal stability of 5-Fluorouracil nanoparticles which indicated a well-established structure of nanoparticles.

Keywords

Chitosan

Gelycerol Moonoleate

Magnetic nanoparticles

Targeted delivery

5-Fluorouracil

Subjects

Biomedical Enginireeng

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