Volume 3, Issue 4 (2020)
IQBQ 2020, 3(4): 73-83 |
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jahansooz F, ebrahimi hosseinzade B, Hatamian-Zarmi A, Shahpasand K. Investigation of the Structural Properties of Dopamine-Loaded Poly(butyl cyanoacrylate) Nanosystem. IQBQ 2020; 3 (4) :73-83
URL: http://arcpe.modares.ac.ir/article-38-37164-en.html
URL: http://arcpe.modares.ac.ir/article-38-37164-en.html
Fatemeh Jahansooz1 
, Bahaman Ebrahimi hosseinzade 2, Ashrafalsadat Hatamian-Zarmi3 , Koorosh Shahpasand3
, Bahaman Ebrahimi hosseinzade 2, Ashrafalsadat Hatamian-Zarmi3 , Koorosh Shahpasand3
1- student
2- assistant proffesor ,bahman.ebrahimi@ut.ac.ir
3- assistant professor
2- assistant proffesor ,
3- assistant professor
Abstract: (4551 Views)
Research subject: Parkinson’s disease is a neurodegnerative disorder with no treatment due to the blood brain barrier (BBB) existence. The cure for this disease is Dopamine a chemical molecule.
Research approach: This study investigates biodegradable naoparticles (NPs) carrying dopamine (DA) across the blood–brain barrier. Ion polymerization and solvent methods were used to achieve this goal. Particle size, zeta potential, entrapment efficiency and in vitro drug release behavior, at pH 7 were examined.
Main results: The empty nanoparticles and drug-loaded nanoparticles were found to be spherical in shape and fluffy exterior, with mono-modal size distribution and negative zeta-potentials of increasing average sizes 90 to 120 nm simultaneously. Fourier transform infrared (FTIR) spectra demonstrated the polymerization of nBCA monomers and encapsulation of DA inside poly (butylcyanoacrylate) (PBCA).Thermal characteristics of the copolymer were investigated by Fourier-transform infrared spectroscopy (FTIR). Drug loading efficiency was around 25%.The in-vitro drug release profile of DA -loaded PBCA nanoparticles prepared from ion polymerization following solution techniques exhibited a gradual release; more than 20 ٪w/w of the drug was released after 51 h. The results showed that the DA–PBCA nanocapsules could be an effective carrier for hydrophilic agents. In this study, PBCA-NSPs were successfully generated as a delivery system for DA, providing a promising approach to improve the therapy of PDs.
Research approach: This study investigates biodegradable naoparticles (NPs) carrying dopamine (DA) across the blood–brain barrier. Ion polymerization and solvent methods were used to achieve this goal. Particle size, zeta potential, entrapment efficiency and in vitro drug release behavior, at pH 7 were examined.
Main results: The empty nanoparticles and drug-loaded nanoparticles were found to be spherical in shape and fluffy exterior, with mono-modal size distribution and negative zeta-potentials of increasing average sizes 90 to 120 nm simultaneously. Fourier transform infrared (FTIR) spectra demonstrated the polymerization of nBCA monomers and encapsulation of DA inside poly (butylcyanoacrylate) (PBCA).Thermal characteristics of the copolymer were investigated by Fourier-transform infrared spectroscopy (FTIR). Drug loading efficiency was around 25%.The in-vitro drug release profile of DA -loaded PBCA nanoparticles prepared from ion polymerization following solution techniques exhibited a gradual release; more than 20 ٪w/w of the drug was released after 51 h. The results showed that the DA–PBCA nanocapsules could be an effective carrier for hydrophilic agents. In this study, PBCA-NSPs were successfully generated as a delivery system for DA, providing a promising approach to improve the therapy of PDs.
Article Type: Original Research |
Subject:
Drug delivery
Received: 2019/10/8 | Accepted: 2020/03/27 | Published: 2020/03/27
Received: 2019/10/8 | Accepted: 2020/03/27 | Published: 2020/03/27
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