Determination of nucleation and induction time of crystallization of amoxicillin nanoparticles in the presence of surface active agents

Manteghian, Mehrdad; Parvin, Paria

Determination of nucleation and induction time of crystallization of amoxicillin nanoparticles in the presence of surface active agents

Document Type : Original Research

Authors

M. Manteghian ¹

P. parvin ²

¹ Faculty of Chemical Engineering Department, Tarbiat Modares University, Tehran, Iran,

² Chemical Engineering Department, Islamic Azad University, Science & Research Boushehr Branch, Boushehr, Iran

Abstract

Research subject: The use of nanoparticles, especially nano-antibiotics, increases their efficacy. More uniform release of antibiotics is one of the benefits of being nano. They can also be made using ointment or banderol to absorb through the skin to the infection, thereby reducing its side effects. Amoxicillin is one of the most widely used antibiotics in the world which can be prevented by increasing the use of other strong antibiotics if promoted as nanoparticles. Determining the mechanism of nanoparticle formation of this drug is an important factor for its commercial production.

Research approach: The purpose of this study was to determine the nucleation mechanism and time of induction of crystallization of amoxicillin nanoparticles in the presence of surface active agents ‘CTAB’ and ‘SDS’. Therefore, the effect of amoxicillin concentration and stabilizing concentration on the crystallization process was investigated. In this project, a combination of inductive-reactive crystallization was used. In this method, amoxicillin sodium was produced with sodium hydroxide, amoxicillin sodium, has a much higher solubility in water. Then, by adding hydrochloric acid, amoxicillin will be recovered and supersaturated. SEM and DLS analyzes were used to determine the properties of amoxicillin nanoparticles. All the experiments were repeated twice.

Main results: The results show that particles with a mean size of 50 nm were formed, and the particle stability was confirmed up to one week after formation. The results of the experiments show that the nucleation mechanism is the primary type with an average explanatory factor (R²) equal to 0.9887 and adding a stabilizing agent has no effect on the nucleation mechanism.

Keywords

Induction-Crystallisation

amoxicillin

Induction Time

Nuclear Mechanism

stabilizer

Subjects

Drug delivery

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